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Research

Syntheses of molecules and their studies with various spectroscopies are current interest in our laboratories. We are experts in syntheses of peptides modified with several chromophores, fluorophores, metal binders, anti-oxidants, etc. Currently, our aims are syntheses of amyloidogenic peptides and proteins including Abeta1-42 (Sedlák et al. 2013), alpha-synuclein (Niederhafner et al. 2016), and prion protein (Zawada et al. 2013). We are interested in oxidative stress induced modification of proteins such as incorporation of 3-nitro-L-tyrosine (Niederhafner et al. 2016).

The most important achievements are (i) solution and solid phase syntheses of aryl peptide conjugates which opened a way for syntheses of head-and-tail bis-arylated peptides directly on resin (Šebestík et al. 2004) (ii) Raman optical activity (ROA) spectra and magnetic ROA of various gases (first-ever ROA spectrum reported in the gas phase despite very low concentration of the compound for common ROA measurement (Šebestík and Bouř 2011, Šebestík and Bouř 2014, Šebestík et al. 2016)); and (iii) density functional theory based assignment of UV-Vis and Raman spectra of ferric-deferiprone complex and prediction of an isomer unseen by X-ray (Šebestík et al. 2012). Furthermore, an invited book (Šebestík J., Reiniš M., Ježek J. Biomedical Applications of Peptide-, Glyco- and Glycopeptide Dendrimers, and Analogous Dendrimeric Structures. Wien, Austria: Springer-Verlag 2012) has been published. JS delivered 11 lectures on international and national meetings including one plenary lecture. JS participated in public relation events such as Open Science II-IV, Chemical Market, and Museum Night. JS has been an adviser for two M. Sc. and two Ph. D. students. Within frameworks of Open Science II-V granted by European social fund, JS supervises 4 high school students, who have opportunity to work in research laboratory. JS has been participating in solving of 9 grants as a member of team and 1 as principal investigator.

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